Cough after inhalation of corticosteroids delivered from spacer devices in children with asthma
Identifieur interne : 000E53 ( France/Analysis ); précédent : 000E52; suivant : 000E54Cough after inhalation of corticosteroids delivered from spacer devices in children with asthma
Auteurs : Jean-Christophe Dubus [France] ; Laurent Mély [France] ; Laetitia Huiart [France] ; Christophe Marguet [France] ; Pascal Le Roux [France]Source :
- Fundamental & Clinical Pharmacology [ 0767-3981 ] ; 2003-10.
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Abstract
Children using a spacer device rather than another device for delivering inhaled corticosteroids (ICS) has been identified as a risk factor for cough immediately after inhalation. The aim of this study was to point out the different factors influencing the occurrence of such lateral side‐effects. We studied this local side‐effect in 402 asthmatic children (55.6 ± 34.9 months; 65.6% boys) treated for at least 1 month with beclomethasone dipropionate (n = 331), budesonide (n = 47) or fluticasone propionate (n = 24) delivered from pressurized metered‐dose inhalers and small (75.1%) or large volume (24.8%) spacer devices mainly used with face mask (90.7%). A total of 219 patients (54.5%), treated with either high doses of ICS or ICS and long‐acting β2‐agonist, were considered as having severe asthma. Cough was reported after each inhalation of corticosteroids in 216 patients (53.7%). Among them, about 30% also complained of cough with β2‐agonists. Despite different propellants and dispersants, all corticosteroids induced cough similarly. Cough was not linked with asthma severity, but was significantly related to therapy duration and use of long‐acting β2‐agonist. Type and volume of the spacer device, use of a face mask or mouthpiece were not influencing factors. Cough after inhalation of corticosteroids delivered from spacer devices is a frequent local side‐effect in children with asthma. This side effect can greatly alter compliance. A practitioner must be sought at each visit.
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DOI: 10.1046/j.1472-8206.2003.00191.x
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The aim of this study was to point out the different factors influencing the occurrence of such lateral side‐effects. We studied this local side‐effect in 402 asthmatic children (55.6 ± 34.9 months; 65.6% boys) treated for at least 1 month with beclomethasone dipropionate (n = 331), budesonide (n = 47) or fluticasone propionate (n = 24) delivered from pressurized metered‐dose inhalers and small (75.1%) or large volume (24.8%) spacer devices mainly used with face mask (90.7%). A total of 219 patients (54.5%), treated with either high doses of ICS or ICS and long‐acting β2‐agonist, were considered as having severe asthma. Cough was reported after each inhalation of corticosteroids in 216 patients (53.7%). Among them, about 30% also complained of cough with β2‐agonists. Despite different propellants and dispersants, all corticosteroids induced cough similarly. Cough was not linked with asthma severity, but was significantly related to therapy duration and use of long‐acting β2‐agonist. Type and volume of the spacer device, use of a face mask or mouthpiece were not influencing factors. Cough after inhalation of corticosteroids delivered from spacer devices is a frequent local side‐effect in children with asthma. This side effect can greatly alter compliance. A practitioner must be sought at each visit.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Provence-Alpes-Côte d'Azur</li><li>Région Normandie</li></region><settlement><li>Le Havre</li><li>Marseille</li><li>Rouen</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Dubus, Jean Hristophe" sort="Dubus, Jean Hristophe" uniqKey="Dubus J" first="Jean-Christophe" last="Dubus">Jean-Christophe Dubus</name></region><name sortKey="Huiart, Laetitia" sort="Huiart, Laetitia" uniqKey="Huiart L" first="Laetitia" last="Huiart">Laetitia Huiart</name><name sortKey="Marguet, Christophe" sort="Marguet, Christophe" uniqKey="Marguet C" first="Christophe" last="Marguet">Christophe Marguet</name><name sortKey="Mely, Laurent" sort="Mely, Laurent" uniqKey="Mely L" first="Laurent" last="Mély">Laurent Mély</name><name sortKey="Roux, Pascal Le" sort="Roux, Pascal Le" uniqKey="Roux P" first="Pascal Le" last="Roux">Pascal Le Roux</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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